Pharmacology of o-chlorobenzylidene malononitrile (CS)
نویسندگان
چکیده
منابع مشابه
CS gas exposure in a crowded night club: the consequences for an accident and emergency department.
A case is reported of deliberate release of CS gas (O-chlorobenzylidene malononitrile) in an enclosed space and the consequences for an accident and emergency department.
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The aim of this study was to determine whether o-chlorobenzylidene malononitrile ( CS) exhibits any genotoxic activity towards Salmonella or mammalian DNA in vivo. CS was synthesized with a [14C]-label at the benzylic carbon atom. It was administered i. p. at a dose Ievel of 13 mg/kg (1 mCi/kg) to young adult male rats. Liverand kidney DNA was isolated after 8, 25, and 75 h. The radioactivity w...
متن کاملPolarographic determination of malononitrile.
A procedure is proposed for the determination of malononitrile by differential pulse polarography in methanolic 0.1M tetraethylammonium iodide/0.001M tetramethylammonium hydroxide as the supporting electrolyte. In this medium malononitrile is chemically converted into an electroactive species. With close control of timing of the steps in the procedure the error of the method is +/-1.5% in the c...
متن کاملIn vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model
AZ465 is a novel selective transient receptor potential cation channel, member A1 (TRPA1) antagonist identified during a focused drug discovery effort. In vitro, AZ465 fully inhibits activation by zinc, O-chlorobenzylidene malononitrile (CS), or cinnamaldehyde of the human TRPA1 channel heterologously expressed in human embryonic kidney cells. Our data using patch-clamp recordings and mouse/hum...
متن کامل2-(4-Nitrobenzylidene)malononitrile
In the title compound, C(10)H(5)N(3)O(2), the benzyl-idene-malono-nitrile unit is nearly planar, with a maximum deviation of 0.129 (2) Å for a terminal N atom; the nitro group is approximately coplanar with the benzene ring [dihedral angle = 8.8 (3)°]. An intra-molecular C-H⋯N hydrogen bond stabilizes the mol-ecular conformation.
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1972
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1972.tb07293.x